795 MYOCARDIAL WORK AND LEFT HEART DEFORMATION PARAMETERS ACROSS MITRAL REGURGITATION SEVERITY

Abstract Background Myocardial work (MW) estimation by pressure-strain loops using an implemented speckle tracking software has showed to estimate LV contractile properties overcoming the load-dependency limit of left ventricular (LV) global longitudinal strain (GLS). This proved useful particularly in clinical setting characterized frequent hemodynamic variations, such as heart failure and valvular disease. However, variation MW parameters across different stages mitral regurgitation (MR) its impact on symptoms never been investigated. Objective The aim this observational study was assess variations deformation chambers mild, moderate severe MR. Methods consecutive patients with MR were prospectively enrolled. Exclusion criteria were: chronic atrial fibrillation, prosthesis, previous cardiac surgery.Clinical evaluation, blood sample tests, ECG echocardiography performed. Speckle analysis completed myocardial performed offline. Patients then divided into groups first according severity. Differences among analyzed student T test (or non-parametric tests for non-normally distributed variables) predictors (as NYHA class ≥ 2) explored logistic regression analysis. Results overall, 120 enrolled (40 40 moderate, MR). GLS improved severity, while Global PALS reduced constructive (GCW) wasted (GWW) significantly MR, efficiency (GWE) a trend towards reduction higher grades index did not changed three (Fig.1). Among parameters, emerged predictor (R2=0.2, p<0.001) These results are explained pathophysiology mechanism attempted compensation volume overload increased contractility parallel disease progress, although low efficacy increasing stroke work; LA diastolic function have early which is associated occurrence symptoms. Conclusions accurately reflect pathophysiologic mechanisms burden Fig. 1 2